Thanks Mikkel for testing it.

I suggest that you (or some other Windows-guy) make a small example
program using pyOpenSSL and see if you can make that work.

Then try with an example Twisted program using OpenSSL. There is an
example client and server here:

http://twistedmatrix.com/trac/browser/trunk/doc/core/examples/echoserv_ssl.py
http://twistedmatrix.com/trac/browser/trunk/doc/core/examples/echoclient_ssl.py